Document Detail

A 5-year evaluation of NORPLANT contraceptive implants in China.
MedLine Citation:
PMID:  8164924     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the efficacy, safety, and acceptability of NORPLANT implants when used by Chinese women. METHODS: In a prospective, multicenter clinical trial, 10,718 women selecting NORPLANT implants were monitored semiannually for the first 2 study years and then annually through 5 years. Life table rates of pregnancy and other terminations were calculated, as were incidence rates of serious conditions leading to termination. RESULTS: The 5-year average annual pregnancy rate was 0.3 per 100 and the ectopic pregnancy rate was minimal, 0.09 per 1000 woman-years. Pregnancy rates correlated significantly with weight, but regardless of weight group, annual average pregnancy rates were less than one per 100. Younger women experienced higher pregnancy rates than did older users. Headache, myoma, dizziness, and weight gain led more frequently to termination than did other adverse events apart from menstrual disturbances. Mortality during use was 2.0 per 10,000 years, based on 44,954 years of experience. There were no cardiovascular or cerebrovascular deaths, and no deaths were attributable to NORPLANT use. Seventy-two per 100 initial acceptors used the implants continuously for 5 years. CONCLUSION: NORPLANT implants proved highly effective, safe, and acceptable among Chinese women regardless of province, age, or weight at admission.
S J Gu; M K Du; L D Zhang; Y L Liu; S H Wang; I Sivin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  83     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-8     Citation Subset:  AIM; IM    
Municipal Research Institute of Family Planning, Beijing, China.
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MeSH Terms
Contraceptive Agents, Female / adverse effects*
Drug Implants
Follow-Up Studies
Levonorgestrel / adverse effects*
Menstruation Disturbances / chemically induced,  epidemiology
Pregnancy / statistics & numerical data
Prospective Studies
Thrombocytopenia / chemically induced,  epidemiology
Reg. No./Substance:
0/Contraceptive Agents, Female; 0/Drug Implants; 797-63-7/Levonorgestrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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