| 5-[[omega-(Dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo [2.2.2.]octan-6-ones with hypotensive, local anesthetic, antiarrhythmic and other activities. | |
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MedLine Citation:
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PMID: 7811348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of 5-[[omega-(dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2- oxabicyclo[2.2.2]octan-6-ones by reaction of (+)-5-(hydroxymethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan- 6-one with a series of omega-(chloroalkyl)dialkylamines in the presence of potassium carbonate is described. Some compounds showed strong hypotensive, local anesthetic and antiarrhythmic activity in rats and mice, as well as moderate analgesic, antipyretic and in vitro platelet antiaggregating activity. |
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Authors:
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S Schenone; O Bruno; A Ranise; F Bondavalli; M D'Amico; M Piu; W Filippelli; L Berrino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 49 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
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Languages: eng Pagination: 541-4 Citation Subset: IM |
Affiliation:
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Istituto di Scienze Farmaceutiche dell'Università, Genova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Non-Narcotic
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chemical synthesis,
pharmacology Anesthetics, Local / chemical synthesis*, pharmacology Animals Anti-Arrhythmia Agents / chemical synthesis*, pharmacology Antihypertensive Agents / chemical synthesis*, pharmacology Bicyclo Compounds / chemical synthesis*, pharmacology Mice Platelet Aggregation Inhibitors / chemical synthesis, pharmacology Rats |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 0/Anesthetics, Local; 0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Bicyclo Compounds; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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