| The 5-hydroxytryptamine1A receptor agonist, (+)-8-hydroxy-2-(di-n-propylamino)-tetralin, increases cardiac output and renal perfusion in rats subjected to hypovolemic shock. | |
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MedLine Citation:
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PMID: 17085544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 5-hydroxytryptamine(1A) receptor agonist, (+)-8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), raises blood pressure (BP) and venous tone in rats subjected to hemorrhagic shock. Here, BP, ascending aortic blood flow [i.e., estimate of cardiac output (CO)] and venous blood gases were measured to determine the hemodynamic effects of 8-OH-DPAT (30 nmol/kg i.v., n = 10), saline (n = 10), or an equipressor infusion of epinephrine (n = 10) in unanesthetized rats subjected to hemorrhagic shock (25 min of hypotensive hemorrhage, approximately 50 mm Hg). Renal and iliac blood flow were measured in separate groups of similarly hemorrhaged rats given the same dose of 8-OH-DPAT (n = 7) or saline (n = 6). Compared with saline treatment, 8-OH-DPAT produced a sustained rise in BP (+32 +/- 4 versus +9 +/- 2 mm Hg, 15 min after injection, P < 0.01) and CO (+27 +/- 5 versus +4 +/- 6 ml/min/kg, P < 0.01) but did not affect total peripheral resistance (TPR). Infusion of epinephrine reduced CO (-12 +/- 6 ml/min/kg, P < 0.01) and dramatically increased TPR [+0.37 +/- 0.11 versus +0.05 +/- 0.05 log (mm Hg/ml/min/kg), P < 0.01]. 8-OH-DPAT increased renal conductance (+7 +/- 1 versus +4 +/- 1 microl/min/mm Hg, P < 0.01) but did not significantly affect iliac conductance. 8-OH-DPAT attenuated further development of acidosis compared with either saline or epinephrine (-5.6 +/- 1.6 versus -13.0 +/- 2.0 versus -11.3 +/- 2.6 mmol/liter base excess 45 min after start of hemorrhage, both P < 0.01 versus 8-OH-DPAT). These data demonstrate that 8-OH-DPAT improves hemodynamics during circulatory shock, in part, through renal vasodilation and mobilizing of blood stores. |
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Authors:
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Ruslan Tiniakov; Patrick Osei-Owusu; Karie E Scrogin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-03 |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 320 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-22 Completed Date: 2007-03-13 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: United States |
Other Details:
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Languages: eng Pagination: 811-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, IL, USA |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Hydroxy-2-(di-n-propylamino)tetralin
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pharmacology* Animals Blood Pressure / drug effects Carbon Dioxide / blood Cardiac Output / drug effects* Epinephrine / pharmacology Heart Rate / drug effects Ilium / blood supply, drug effects Male Norepinephrine / pharmacology Rats Rats, Sprague-Dawley Renal Circulation / drug effects* Serotonin 5-HT1 Receptor Agonists* Serotonin Receptor Agonists / pharmacology* Shock / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL072354-07/HL/NHLBI NIH HHS; R01 HL076162/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serotonin 5-HT1 Receptor Agonists; 0/Serotonin Receptor Agonists; 124-38-9/Carbon Dioxide; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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