| 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. | |
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MedLine Citation:
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PMID: 19590397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genes that regulate the serotonin signalling system are potential targets for research in the aetiology of mood disorders and also in the treatment response of serotonin reuptake inhibitors. In this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms [HTR1A (rs6295), HTR2A (rs6313, rs6311 and rs7997012), HTR6 (rs1805054), TPH1 (rs1800532) and TPH2 (rs1386494)] with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors. Patients who met the criteria for major depressive disorder were treated for 6 weeks with fluoxetine, paroxetine or citalopram. The treatment response was evaluated with the Montgomery-Asberg Depression Rating Scale, and according to predefined response criteria, the patients were divided into responders, nonresponders, remitters and nonremitters. Altogether, 86 patients completed the entire study according to the study protocol. We had also a control population (N = 395) of healthy blood donors. None of the seven single nucleotide polymorphisms was associated with major depressive disorder or with treatment response in our study population of Finnish individuals. |
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Authors:
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Ari Illi; Eija Setälä-Soikkeli; Merja Viikki; Outi Poutanen; Heini Huhtala; Nina Mononen; Terho Lehtimäki; Esa Leinonen; Olli Kampman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 20 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1125-8 Citation Subset: IM |
Affiliation:
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University of Tampere, Medical School, Tampere, Finland. ari.illi@uta.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Citalopram / therapeutic use Depressive Disorder, Major / drug therapy*, genetics* Fluoxetine / therapeutic use Humans Middle Aged Paroxetine / therapeutic use Polymorphism, Single Nucleotide* Psychiatric Status Rating Scales Receptor, Serotonin, 5-HT1A / genetics Receptor, Serotonin, 5-HT2A / genetics Receptors, Serotonin / genetics Serotonin Uptake Inhibitors / therapeutic use* Treatment Outcome Tryptophan Hydroxylase / genetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Serotonin, 5-HT2A; 0/Receptors, Serotonin; 0/Serotonin Uptake Inhibitors; 0/serotonin 6 receptor; 112692-38-3/Receptor, Serotonin, 5-HT1A; 54910-89-3/Fluoxetine; 59729-33-8/Citalopram; 61869-08-7/Paroxetine; EC 1.14.16.4/TPH1 protein, human; EC 1.14.16.4/TPH2 protein, human; EC 1.14.16.4/Tryptophan Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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