| 5-azacytidine treatment induces autoimmune vitiligo in parental control strains of the Smyth line chicken model for autoimmune vitiligo. | |
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MedLine Citation:
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PMID: 8906744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of 5-Azacytidine (5-AzaC) on melanization was examined in two sublines of the Smyth line (SL) chicken model for autoimmune vitiligo, in two MHC-matched vitiligo-susceptible but normally pigmented controls (BL), and in nonsusceptible controls (LBL). 5-AzaC was administered ip every 3 days from day of hatch to 18 weeks at levels of 1 or 3 mg/kg body wt. Both treatments increased (P < 0.01) the incidence of autoimmune vitiligo in BL controls. In contrast, treatment significantly depressed (P < 0.01) the expected high incidence of vitiligo in one SL subline, but not in the other. There were no apparent pigmentation changes in 5-AzaC-treated LBL controls. 5-AzaC had dose-dependent depressing effects (P < 0.01) on body and lymphoid organ weights. Histological and mitogen assay data suggest negative effects on lymphocyte number and function. The data show that 5-AzaC can initiate autoimmune disease in genetically susceptible but phenotypically normal individuals. |
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Authors:
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G P Sreekumar; G F Erf; J R Smyth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 81 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 136-44 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst 01003, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / chemically induced* Azacitidine / administration & dosage, adverse effects* Body Weight Chickens / immunology* Disease Models, Animal Erythrocyte Count / drug effects Feathers / anatomy & histology, embryology Incidence Leukocyte Count / drug effects Lymphocyte Activation / drug effects Lymphoid Tissue / anatomy & histology Organ Size Vitiligo / chemically induced, epidemiology, immunology* |
| Chemical | |
Reg. No./Substance:
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320-67-2/Azacitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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