| 5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes. | |
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MedLine Citation:
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PMID: 19774649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Epidemiological data suggests that 5-aminosalicylic acid (5-ASA), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood. METHODS AND RESULTS: Here we report that 5-ASA prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an S-phase and G2/M phase arrest, dependent on 5-ASA dosage and concentration, together with an increased mitotic index. In addition, prolonged cell cycle arrest by repeated 5-ASA treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death. CONCLUSION: These observations illustrate that 5-ASA has chemopreventive and chemotherapeutic properties. |
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Authors:
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Pim J Koelink; Marij A C Mieremet-Ooms; Willem E Corver; Kamila Wolanin; Daniel W Hommes; Cornelis B H W Lamers; Hein W Verspaget |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inflammatory bowel diseases Volume: 16 ISSN: 1536-4844 ISO Abbreviation: Inflamm. Bowel Dis. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508162 Medline TA: Inflamm Bowel Dis Country: United States |
Other Details:
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Languages: eng Pagination: 379-89 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, and Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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pharmacology* Apoptosis / drug effects* Caco-2 Cells Cell Division / drug effects Colorectal Neoplasms / drug therapy*, pathology* Flow Cytometry G2 Phase / drug effects HCT116 Cells HT29 Cells Humans Mesalamine / pharmacology* Microtubule-Associated Proteins / metabolism Mitosis / drug effects Mitotic Spindle Apparatus / drug effects, pathology PPAR gamma / metabolism S Phase / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/BIRC5 protein, human; 0/Microtubule-Associated Proteins; 0/PPAR gamma; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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