Document Detail

5 years review of periocular basal cell carcinoma and proposed follow-up protocol.
MedLine Citation:
PMID:  23154501     Owner:  NLM     Status:  MEDLINE    
AIM: (1) To investigate the recurrence of periocular basal cell carcinoma (BCC) reported as completely excised on histology. (2) To identify risks associated with recurrence. (3) To recommend a rational follow-up protocol.
METHODS: This is a cohort study by case note review of consecutive patients undergoing excision of periocular BCC between 2000 and 2006 at University Hospitals of Leicester. All lesions were excised with 3 mm clinical margin and the defect reconstructed only after the excision margin was declared clear.
RESULTS: A total of 413 episodes of surgical excision were recorded for 270 patients over the 7-year period of 2000-2006. All of them have 5 years follow-up. Mean age 73.7 (±12.5). In all, 67% were nodular BCC and 45.4% located in the lower eyelid. The main outcome measure was the recurrence rate. None of the patients with primary nodular BCC suffered recurrence. The recurrence rate for primary morphoeaform BCC following complete excision is 3.8%. In total, 8.1% of patients had several lesions simultaneously whereas 7.8% patients had BCC in multiple locations subsequently (metachronous). Three patients who had previously recurrent BCC (rBCC) treated elsewhere or not using this method had orbital/lacrimal drainage system involvement requiring exenteration.
CONCLUSION: We recommend that patients with a single, completely excised primary solid or nodular BCC can be discharged after one 6-monthly review, although they should be instructed to monitor for the development of further lesions. The incidence of recurrence for primary morphoeaform BCC is 3.8% and for rBCC is 3.6% over 5 years and these patients should stay under review for this period.
S F Ho; L Brown; M Bamford; R Sampath; J Burns
Publication Detail:
Type:  Journal Article     Date:  2012-11-16
Journal Detail:
Title:  Eye (London, England)     Volume:  27     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-04     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Carcinoma, Basal Cell / epidemiology*,  surgery
Cohort Studies
Eyelid Neoplasms / epidemiology*,  surgery
Great Britain / epidemiology
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Retrospective Studies
Risk Factors
Skin Neoplasms / epidemiology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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