| 5-(N-Ethyl-N-isopropyl)-amiloride inhibits amino acid release from the ischemic rat cerebral cortex: role of Na+-H+ exchange. | |
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MedLine Citation:
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PMID: 9813378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the selective Na+/H+ antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on amino acid release from the ischemic/reperfused rat cerebral cortex was investigated using a cortical cup technique. EIPA (25 microM in artificial cerebrospinal fluid), applied topically, inhibited the ischemia-reperfusion evoked efflux of aspartate, glutamate, gamma-aminobutyric acid, taurine and phosphoethanolamine. Reductions in the ischemia-evoked releases of these amino acids suggest that ischemia precipitates acidosis, Na+/H+ exchange and cell swelling with amino acid release as the cells mount a regulatory volume decrease response. EIPA, by blocking Na+/H+ exchange, would reduce cell swelling and the resulting amino acid release. |
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Authors:
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J W Phillis; M H O'Regan; D Song |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 812 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-02-10 Completed Date: 1999-02-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 297-300 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Elsevier Science B.V. |
Affiliation:
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Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA. jphillis@med.wayne.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiloride
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analogs & derivatives*,
pharmacology Amino Acids / metabolism* Animals Brain Ischemia / drug therapy* Male Rats Rats, Sprague-Dawley Sodium-Hydrogen Antiporter / antagonists & inhibitors* |
| Grant Support | |
ID/Acronym/Agency:
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NS26912-09/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Sodium-Hydrogen Antiporter; 1154-25-2/ethylisopropylamiloride; 2609-46-3/Amiloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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