Document Detail

5-Methoxyindoles in pineal gland of cow, pig, sheep and rat.
MedLine Citation:
PMID:  6173774     Owner:  NLM     Status:  MEDLINE    
The occurrence and concentration of the four 5-methoxyindoles: 5-methoxtryptamine, 5-methoxytryptophol, 5-methyoxyindole-3-acetic acid and melatonin in the pineal gland of pig, cow, sheep and rat was investigated. The analytical method involved the use of deuterated analogues as internal standards and capillary column gas chromatography - mass spectrometry. The analyses of pineal glands obtained during the morning hours revealed the presence of 5-methoxyindole-3-acetic acid and melatonin in nmoles/g and 5-methyoxytryptophol and 5-methoxytryptamine in pmoles/g amounts in pig, cow and sheep. In Wistar and Sprague-Dawley strain of rat, melatonin was present at a concentration of about 0.5 pmoles/pineal, a level which was elevated more than five times by treatment with a monoamine oxidase inhibitor. 5-Methoxytryptamine was found at a concentration of about 0.03 pmoles/pineal, and was elevated by monoamine oxidase inhibition.
O Beck; G Jonsson; A Lundman
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  318     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
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MeSH Terms
5-Methoxytryptamine / metabolism
Gas Chromatography-Mass Spectrometry / methods
Hydroxyindoleacetic Acid / analogs & derivatives,  metabolism
Indoles / metabolism*
Melatonin / metabolism
Pineal Gland / metabolism*
Rats, Inbred Strains
Species Specificity
Grant Support
Reg. No./Substance:
0/Indoles; 3471-31-6/5-methoxyindoleacetic acid; 54-16-0/Hydroxyindoleacetic Acid; 608-07-1/5-Methoxytryptamine; 712-09-4/methoxytryptophol; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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