Document Detail

5-Hydroxytryptophan effect on the development of the immune response: IgM and IgG antibodies and rosette formation in primary and secondary responses.
MedLine Citation:
PMID:  1086239     Owner:  NLM     Status:  MEDLINE    
In animals immunized with bovine serum albumin, 5-hydroxytryptophan prolonged the latent period of the IgM and IgG primary responses, decreased response intensity, delayed the response peak and suppressed IgG immunological memory. In 5-hydroxytryptophan-treated mice, the number of rosette-forming cells (RFC) in the lymph node and spleen decreased during the primary and secondary responses. This effect was due to the decreased number of IgG RFC and to the later involvement of IgM RFC in the immune response. The absence of the secondary response was related to unprimed IgG memory cells. 5-hydroxytryptophan does not inhibit the primary and secondary responses after the connections between the hypothalamus and pituitary have been disrupted. The participation of the n.raphe-hypothalaminc-pituitary system in immuno-regulation and the putative mechanism underlying serotonin effect on the immune response are discussed.
L Devoino; L Eliseeva; O Eremina; G Idova; M Cheido
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  5     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  394-9     Citation Subset:  IM    
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MeSH Terms
5-Hydroxytryptophan / pharmacology*
Antibody Formation / drug effects*
Hypothalamo-Hypophyseal System / immunology
Immune Adherence Reaction
Immunization Schedule
Immunoglobulin G / biosynthesis*
Immunoglobulin M / biosynthesis*
Immunologic Memory / drug effects*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 56-69-9/5-Hydroxytryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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