| 5-Hydroxytryptamine--a local regulator of testicular blood flow and vasomotion in rats. | |
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MedLine Citation:
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PMID: 8667341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 5-hydroxytryptamine (5-HT), 5-HT2 receptor antagonists (ritanserin and ketanserin), histamine and substance 48/80 on testicular blood flow and microcirculation were studied in adult rats. The substances were administered by topical application on the testicular surface and by intratesticular injections, and blood flow was measured by radioactive microspheres and with a laser Doppler flowmeter. Blood flow was decreased by 5-HT in a dose-dependent manner and vasomotion in the testis was inhibited, suggesting that it could be involved in the physiological regulation of the testicular vasculature. The 5-HT antagonists did not significantly influence flow or vasomotion in intact testes. Histamine did not cause any major effects on testicular blood flow. Substance 48/80 caused degranulation of testicular mast cells, and reduced testicular blood flow and vasomotion suggesting that testicular mast cells, possibly by releasing 5-HT, could be involved in the local control of the testicular vasculature. |
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Authors:
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O Collin; J E Damber; A Bergh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of reproduction and fertility Volume: 106 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-08-08 Completed Date: 1996-08-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Umeå University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Dose-Response Relationship, Drug Histamine / pharmacology Injections Ketanserin / pharmacology Laser-Doppler Flowmetry Male Microcirculation / drug effects Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Ritanserin / pharmacology Serotonin / pharmacology* Serotonin Agonists / pharmacology* Serotonin Antagonists / pharmacology Testis / blood supply* p-Methoxy-N-methylphenethylamine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Agonists; 0/Serotonin Antagonists; 4091-50-3/p-Methoxy-N-methylphenethylamine; 50-67-9/Serotonin; 51-45-6/Histamine; 74050-98-9/Ketanserin; 87051-43-2/Ritanserin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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