Document Detail


5-HT7 receptors increase the excitability of rat hippocampal CA1 pyramidal neurons.
MedLine Citation:
PMID:  14642852     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the CA1 area of rat hippocampal slices, a combined application of 5-CT, a potent 5-HT(1A) and 5-HT(7) receptor agonist, and WAY 100635, a selective 5-HT(1A) receptor antagonist, resulted in a reversible increase of the CA1 extracellular population spike amplitude. In whole-cell recording from identified pyramidal neurons, the effects of 5-CT applied in the presence of WAY 100635 involved a reduction of the slow afterhyperpolarization (sAHP) and the frequency adaptation of action potential firing, which could be blocked by a specific 5-HT(7) receptor antagonist SB 269970. The results indicate that the activation of 5-HT(7) receptors increases the excitability of hippocampal CA1 pyramidal cells.
Authors:
Krzysztof Tokarski; Agnieszka Zahorodna; Bartosz Bobula; Grzegorz Hess
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  993     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM    
Affiliation:
Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drug Interactions
Electric Stimulation
Excitatory Postsynaptic Potentials / drug effects,  physiology
Hippocampus / cytology*,  drug effects
Male
Phenols / pharmacology
Piperazines / pharmacology
Pyramidal Cells / drug effects,  physiology*
Pyridines / pharmacology
Rats
Rats, Wistar
Receptors, Serotonin / drug effects,  physiology*
Serotonin / metabolism*
Serotonin Antagonists / pharmacology
Sulfonamides / pharmacology
Chemical
Reg. No./Substance:
0/Phenols; 0/Piperazines; 0/Pyridines; 0/Receptors, Serotonin; 0/SB 269970; 0/Serotonin Antagonists; 0/Sulfonamides; 0/serotonin 7 receptor; 146714-97-8/WAY 100635; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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