| 5-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying. | |
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MedLine Citation:
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PMID: 15191908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin type 3 (5-HT(3)) receptors have been shown to participate in the negative-feedback control of food intake. We previously reported that cholecystokinin (CCK)-induced suppression of food intake is partly mediated through 5-HT(3) receptors when rats were tested on a preferred liquid diet, but whether such an effect occurs when they are tested on a solid maintenance diet is unknown. In the present study, we examined the effects of ondansetron, a selective 5-HT(3) antagonist, on CCK-induced suppression of solid chow intake. Intraperitoneal administration of ondansetron significantly attenuated 30- and 60-min CCK-induced reduction of food intake, with suppression being completely reversed by 120 min. It is not known whether 5-HT(3) receptors directly mediate CCK-induced satiation or whether their participation depends on CCK acting as part of a feedback cascade to inhibit ongoing intake. Because CCK-induced inhibition of sham feeding does not depend on additive gastric/postgastric-feedback signals, we examined the ability of ondansetron to reverse CCK-induced satiation in sham-feeding rats. Ondansetron did not attenuate reduction of sham feeding by CCK, suggesting that ondansetron does not directly antagonize CCK-satiation signals. CCK suppresses real feeding through a delay in gastric emptying. Ondansetron could attenuate CCK-induced reduction of food intake by reversing CCK-induced inhibition of gastric emptying. We found that blockade of 5-HT(3) receptors attenuates CCK-induced inhibition of gastric emptying of a solid meal, as well as saline and glucose loads. We conclude that 5-HT(3) receptors mediate CCK-induced satiation through indirect mechanisms as part of a feedback cascade involving inhibition of gastric emptying. |
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Authors:
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Matthew R Hayes; Rachael L Moore; Samit M Shah; Mihai Covasa |
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Publication Detail:
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Type: Journal Article Date: 2004-06-10 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 287 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2004-10-20 Revised Date: 2006-07-26 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R817-23 Citation Subset: IM |
Affiliation:
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Dept. of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State Univ., 126 South Henderson, University Park, PA 16802, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Depressants* Cholecystokinin / pharmacology* Eating / drug effects* Feedback / drug effects, physiology Gastric Emptying / drug effects*, physiology* Glucose / pharmacology Male Ondansetron / pharmacology Rats Rats, Sprague-Dawley Receptors, Serotonin, 5-HT3 / drug effects, physiology* Satiety Response / drug effects Serotonin Antagonists / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 0/Receptors, Serotonin, 5-HT3; 0/Serotonin Antagonists; 50-99-7/Glucose; 9011-97-6/Cholecystokinin; 99614-02-5/Ondansetron |
| Comments/Corrections | |
Comment In:
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Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R112-4
[PMID:
16690770
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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