| 5-HT3 receptor antagonist ondansetron does not alter effects of amphetamine on DA metabolism. | |
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MedLine Citation:
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PMID: 2151795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was carried out to elucidate the effect of ondansetron, a selective 5-HT3 receptor antagonist, on amphetamine-induced changes in monoamine metabolism in major ascending dopamine (DA) neurons. Amphetamine (2 mg kg-1 s.c.) significantly decreased the concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in nucleus caudatus and nucleus accumbens. Pretreatment with ondansetron (0.1 mg kg-1 and 1 mg kg-1 s.c., 15 min before amphetamine) failed to modify the effects of amphetamine. It is concluded that acute blockade of central 5-HT3 receptors by ondansetron does not prevent amphetamine-induced changes in monoamine metabolism in nigrostriatal or mesolimbic dopaminergic areas. |
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Authors:
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M Koulu; J Lappalainen; J Hietala; B Sjöholm; R Virtanen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 1 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1991-11-13 Completed Date: 1991-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 126-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Turku, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Amphetamine / pharmacology* Animals Biogenic Monoamines / metabolism Brain Chemistry / drug effects* Dopamine / metabolism* Homovanillic Acid / metabolism Imidazoles / pharmacology* Male Neurons / drug effects, metabolism Ondansetron Rats Rats, Inbred Strains Serotonin Antagonists* |
| Chemical | |
Reg. No./Substance:
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0/Biogenic Monoamines; 0/Imidazoles; 0/Serotonin Antagonists; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 300-62-9/Amphetamine; 306-08-1/Homovanillic Acid; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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