Document Detail

The 5-HT2 antagonist ritanserin decreases sleep in cats.
MedLine Citation:
PMID:  8456229     Owner:  NLM     Status:  MEDLINE    
Sleep and wakefulness were recorded in cats after oral administration of the 5-HT2 antagonist ritanserin at doses of 0.5 and 1.0 mg/kg (n = 6), and after 2.5 mg/kg (n = 3). A subgroup (n = 4) of the animals also received the selective 5-HT uptake inhibitor zimeldine and a combination of ritanserin and zimeldine. The drugs were administered shortly after light onset, and sleep was recorded for 15 hours. Waking was increased and slow wave sleep (SWS), particularly deep slow wave sleep (SWS-2), was decreased throughout the recording time after ritanserin administration. Rapid eye movement (REM) sleep latency was increased, and the amount of REM sleep was reduced. In the combination study, ritanserin reduced the delayed SWS increase following the serotonin uptake inhibitor. The findings of increased waking and decreased SWS-2 after ritanserin in cats contrasts with findings from humans and rats where slow wave sleep is increased following ritanserin administration.
L Sommerfelt; R Ursin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sleep     Volume:  16     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-22     Completed Date:  1993-04-22     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Department of Physiology, University of Bergen, Norway.
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MeSH Terms
Behavior, Animal / drug effects,  physiology
Receptors, Serotonin / drug effects*
Ritanserin / pharmacology*
Sleep / drug effects*,  physiology
Sleep Stages / drug effects,  physiology
Wakefulness / drug effects,  physiology
Zimeldine / pharmacology
Reg. No./Substance:
0/Receptors, Serotonin; 56775-88-3/Zimeldine; 87051-43-2/Ritanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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