Document Detail


5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug.
MedLine Citation:
PMID:  1839829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha 1-adrenoceptor antagonist. The IC50 values for alpha 1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same concentration range. The reduction in blood pressure of anesthetized cats by 8-OH-DPAT and urapidil was completely abolished by spiroxatrine, a 5-HT1A antagonist. However, the decreases in blood pressure induced by naftopidil were only partly antagonized by spiroxatrine.
Authors:
H O Borbe; P Metzenauer; I Szelenyi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  205     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  105-7     Citation Subset:  IM    
Affiliation:
ASTA Pharma AG, Department of Biochemistry, Frankfurt/Main, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Antihypertensive Agents / pharmacology*
Cats
Dioxanes / pharmacology
Dopamine Antagonists
Female
Hemodynamics / drug effects
Male
Naphthalenes / pharmacology*
Piperazines / pharmacology*
Radioligand Assay
Rats
Rats, Inbred Strains
Receptors, Serotonin / drug effects*
Spiro Compounds / pharmacology
Tetrahydronaphthalenes / metabolism
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Dioxanes; 0/Dopamine Antagonists; 0/Naphthalenes; 0/Piperazines; 0/Receptors, Serotonin; 0/Spiro Compounds; 0/Tetrahydronaphthalenes; 1054-88-2/spiroxatrine; 57149-07-2/naftopidil; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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