Document Detail


5-HT1A and D-2 receptor affinity of o-methoxyphenylpiperazine derivatives with terminal benzamide fragment on N-4 alkyl chain. 2.
MedLine Citation:
PMID:  7669188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of some o-methoxyphenylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their affinity for dopamine and serotonin receptor subtypes was assayed by in vitro receptor binding. The results show that several derivatives had a good affinity both on D-2 and 5-HT1A receptors, the IC50s ranging from 10(-7) to 10(-8) M.
Authors:
R Perrone; F Berardi; M Leopoldo; V Tortorella; M D Lograno; E Daniele; S Govoni
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  50     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Affiliation:
Dipartimento Farmaco-Chimico, Bari, Italy. off
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacokinetics
Animals
Benzamides / chemistry,  metabolism*,  pharmacology
Binding, Competitive / drug effects
Granisetron / pharmacology
Hippocampus / drug effects,  metabolism
Male
Neostriatum / drug effects,  metabolism
Ondansetron / pharmacology
Piperazines / chemistry,  metabolism*,  pharmacology
Rats
Rats, Wistar
Receptors, Dopamine D2 / drug effects,  metabolism*
Receptors, Serotonin / drug effects,  metabolism*
Spiperone / pharmacology
Synaptic Membranes / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Benzamides; 0/Piperazines; 0/Receptors, Dopamine D2; 0/Receptors, Serotonin; 109889-09-0/Granisetron; 35386-24-4/1-(2-methoxyphenyl)piperazine; 749-02-0/Spiperone; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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