Document Detail


5-HT in systemic hypertension: foe, friend or fantasy?
MedLine Citation:
PMID:  15831089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since its discovery by Erspamer in the 1930s and identification by Page in the 1950s, 5-HT (5-hydroxytryptamine; serotonin) has been an elusive candidate as a substance that plays a role in the disease of high blood pressure, also known as hypertension. In both animal and human hypertension, arterial contraction to 5-HT is profoundly enhanced. Additionally, 5-HT is a vascular smooth muscle cell mitogen. Because both increased arterial contractility and smooth muscle growth contribute to the disease of hypertension, it is logical to believe that 5-HT is a potential cause of disease, and thus a foe. However, decades of research have produced conflicting results as to the potential role of 5-HT in hypertension. This review will discuss historical findings which both support and refute the involvement of 5-HT in hypertension, and pose some new questions that may reveal novel ways for 5-HT to modify vascular control of blood pressure.
Authors:
Stephanie W Watts
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  108     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-15     Completed Date:  2005-06-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-412     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, B445 Life Sciences Building, Michigan State University, East Lansing, MI 48824-1317, USA. watts@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects,  physiology
Disease Models, Animal
Humans
Hypertension / physiopathology*
Rats
Receptors, Serotonin / physiology
Serotonin / metabolism,  pharmacology,  physiology*
Vasoconstriction / drug effects
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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