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5-HT 1A receptors and changes in extracellular 5-HT in the guinea-pig prefrontal cortex: involvement in aversive behaviour.
MedLine Citation:
PMID:  22290997     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The study demonstrates that guinea-pigs handled daily from birth exhibit similar behaviour to rats on the elevated plus maze. Simultaneously performed intra-cortical microdialysis showed that placing guinea-pigs on the elevated plus maze results in an increase in extracellular 5-HT in the frontal cortex. 8-OH-DPAT (0.3 mg/kg s.c.) reduced significantly the increase in cortical extracellular 5-HT and resulted in an 'anxiolytic' profile of behaviour. Pre-treatment with the 5-HT(1) antagonist methiothepin (10.0 mg/kg) antagonized the behavioural effects and prevented the increase in cortical extracellular 5-HT normally produced by exposure to the elevated plus maze. Methiothepin alone had no effect on behaviour in the elevated plus maze. 5-CT (0.1 mg/kg i.p.) abolished the rise in extracellular 5-HT, but did not produce an 'anxiolytic' profile of behaviour on the elevated plus maze. The results show that an increase in cortical extracellular 5-HT occurs in the saline- treated guinea-pig exposed to aversive conditions. It remains to be determined whether the 'anxiolytic' effect of 8-OH-DPAT in the guinea-pig is causally associated with decreased basal extracellular 5-HT. The results however indicate that there is no simple relationship between inhibition of 5-HT release and behaviour indicative of 'anxiolytic' drug actions.
Authors:
A Rex; C A Marsden; H Fink
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  7     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  1993 Jan 
Date Detail:
Created Date:  2012-01-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-45     Citation Subset:  -    
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.
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