Document Detail


5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation.
MedLine Citation:
PMID:  7954023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes two cases of cardiotoxicity associated with the use of 5-fluorouracil (5-FU) in the treatment of neoplastic disease, and reviews the literature to date. The manifestations of cardiac toxicity were significant ventricular dysfunction during continuous infusion of 5-FU, accompanied by symptoms resembling cardiac ischemia in one case and irreversible cardiogenic shock in another. Detailed cardiac investigations and pathological findings provide convincing evidence that the development of acute myocarditis is the likely mechanism of 5-FU cardiotoxicity, rather than coronary insufficiency as has commonly been postulated. Although cardiotoxicity as a complication of 5-FU therapy remains rare, recognition of this entity is important as it may lead to serious hemodynamic compromise and may recur with drug rechallenge.
Authors:
Z Sasson; C D Morgan; B Wang; G Thomas; B MacKenzie; M E Platts
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  10     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  861-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, The Wellesley Hospital, Toronto, Ontario.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adenocarcinoma / drug therapy
Adult
Carcinoma, Squamous Cell / drug therapy
Female
Fluorouracil / adverse effects*,  pharmacology,  therapeutic use
Humans
Lip Neoplasms / drug therapy
Male
Myocarditis / chemically induced*,  physiopathology
Uterine Cervical Neoplasms / drug therapy
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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