| 5-Fluorouracil related toxic myocarditis: case reports and pathological confirmation. | |
MedLine Citation:
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PMID: 7954023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes two cases of cardiotoxicity associated with the use of 5-fluorouracil (5-FU) in the treatment of neoplastic disease, and reviews the literature to date. The manifestations of cardiac toxicity were significant ventricular dysfunction during continuous infusion of 5-FU, accompanied by symptoms resembling cardiac ischemia in one case and irreversible cardiogenic shock in another. Detailed cardiac investigations and pathological findings provide convincing evidence that the development of acute myocarditis is the likely mechanism of 5-FU cardiotoxicity, rather than coronary insufficiency as has commonly been postulated. Although cardiotoxicity as a complication of 5-FU therapy remains rare, recognition of this entity is important as it may lead to serious hemodynamic compromise and may recur with drug rechallenge. |
Authors:
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Z Sasson; C D Morgan; B Wang; G Thomas; B MacKenzie; M E Platts |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 10 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 861-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, The Wellesley Hospital, Toronto, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adenocarcinoma / drug therapy Adult Carcinoma, Squamous Cell / drug therapy Female Fluorouracil / adverse effects*, pharmacology, therapeutic use Humans Lip Neoplasms / drug therapy Male Myocarditis / chemically induced*, physiopathology Uterine Cervical Neoplasms / drug therapy Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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