Document Detail

5-Fluorouracil cardiotoxicity: left ventricular dysfunction and effect of coronary vasodilators.
MedLine Citation:
PMID:  3661619     Owner:  NLM     Status:  MEDLINE    
Seven patients developed clinical features simulating myocardial ischemia less than 72 hours after 12 of 13 separate intravenous 5-fluorouracil administrations; 9 episodes were associated with chest pain, 3 with hypotension, 3 with ventricular tachycardia and 1 with cardiogenic shock. Left ventricular dysfunction was demonstrated by echocardiography in 5 separate episodes, 2 with interval improvement upon repeat echocardiograms. Pretreatment with nitrates and/or calcium channel blockers failed to prevent recurrence of cardiotoxicity during 5 of 6 repeat 5-fluorouracil administrations. Therapy with 5-fluorouracil is associated with cardiotoxicity simulating myocardial ischemia with left ventricular dysfunction. Pretreatment with coronary vasodilators may not prevent this phenomenon.
B Patel; R A Kloner; J Ensley; M Al-Sarraf; J Kish; J Wynne
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  294     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-18     Completed Date:  1987-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  AIM; IM    
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.
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MeSH Terms
Coronary Disease / chemically induced*,  physiopathology,  prevention & control
Fluorouracil / adverse effects*
Heart / drug effects*,  physiopathology
Heart Ventricles / drug effects,  physiopathology
Middle Aged
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Vasodilator Agents; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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