| 5-[(Aminoalkyl)amino]imidazo[4,5,1-de]acridin-6-ones as a novel class of antineoplastic agents. Synthesis and biological activity. | |
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MedLine Citation:
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PMID: 2296035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new class of antineoplastic agents, the 5-substituted imidazo[4,5,1-de]acridin-6-ones with an (aminoalkyl)amino group in the side chain, has been made. These compounds were synthesized by reduction of 1-substituted 4-nitroacridin-9(10H)-ones and subsequent reaction of the derived amines with carboxylic acids. Their cytotoxic activity against HeLaS3 cells in tissue culture and in vivo antitumor activity against P388 leukemia in mice was demonstrated. A strict relationship between the antineoplastic activity and the number of methylene spacers between proximal and distal nitrogens in the side chain was established. |
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Authors:
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W M Cholody; S Martelli; J Paradziej-Lukowicz; J Konopa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 33 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-22 Completed Date: 1990-02-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 49-52 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
/
chemical synthesis,
therapeutic use* Animals Antineoplastic Agents* Chemical Phenomena Chemistry Chemistry, Physical Hela Cells Humans Imidazoles / chemical synthesis, therapeutic use* Leukemia P388 / drug therapy Mice Molecular Structure Physicochemical Phenomena Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Acridines; 0/Antineoplastic Agents; 0/Imidazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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