Document Detail


The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature.
MedLine Citation:
PMID:  17941987     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagulated during pregnancy.
OBJECTIVES: We report a series of 8 patients with this issue and review the current literature.
METHODS: 8 patients (3 of whom were actively pregnant) were referred with histories of spontaneous fetal loss; hypercoaguability work-ups revealed each were homozygous for the MTHFR C677T mutation without other thrombophilias.
RESULTS: In the 3 women who have conceived, treatment with LMW heparin during pregnancy led to two full-term births and one additional pregnancy without complication. For the 5 who have not, we recommended treatment with LMW heparin upon conception.
CONCLUSION: We provide evidence to support the relationship between MTHFR C677T mutations and recurrent fetal loss, and to suggest that anticoagulation of these patients during pregnancy can lead to a successful pregnancy outcome.
Authors:
Ivy Altomare; Alan Adler; Louis M Aledort
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Publication Detail:
Type:  Journal Article     Date:  2007-10-17
Journal Detail:
Title:  Thrombosis journal     Volume:  5     ISSN:  1477-9560     ISO Abbreviation:  Thromb J     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-29     Completed Date:  2011-07-14     Revised Date:  2011-11-21    
Medline Journal Info:
Nlm Unique ID:  101170542     Medline TA:  Thromb J     Country:  England    
Other Details:
Languages:  eng     Pagination:  17     Citation Subset:  -    
Affiliation:
Mount Sinai Medical Center, 1 Gustave L, Levy Pl,, New York, USA. Ivy.Altomare@mssm.edu.
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