Document Detail

40 Years of FCS: How It All Began.
MedLine Citation:
PMID:  23276533     Owner:  NLM     Status:  In-Data-Review    
Fluorescence correlation spectroscopy (FCS) determines rates of molecular transport and chemical reactions from measurements of spontaneous concentration fluctuations in small open sub-volumes of systems in equilibrium or non-equilibrium steady state. The concentration fluctuations are monitored via fluorescence. Although difficult at first, FCS measurements are now in routine use in areas of chemistry, physics and biology. The initial approach has given rise to a wide range of extensions and variations that yield information about the dynamics of molecular processes in simple systems and living cells. FCS provides a window on a mesoscopic world in which molecular fluctuations are both detectable and (for biological cells) possibly functionally important. Moreover, FCS is a precursor to single molecule measurements.
Elliot L Elson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  518     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Campus Box 8231, St. Louis, Missouri, USA. Electronic address:
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