| A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats. | |
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MedLine Citation:
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PMID: 21678997 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Few studies have focused on the toxicological risks of dairy fat intake. A standard dairy fat (SDF) with a 70% SFA content and a naturally enriched dairy fat (EDF) in vaccenic, rumenic and α-linolenic acids and low in SFA (54%) have been examined in a 4-week repeated dose oral toxicity study as a daily dose of 2000 mg/kg bw by gavage in rats. Comparisons were established with a third group of rats (control) which did not receive fat administration. Both fats were well tolerated and no adverse events or mortality were observed during the treatment and neither after a 2-weeks observation period. EDF and SDF did not cause significant differences respect to a control group in body weight gain, food consumption, clinical observations, organ weight ratios, histopathological findings and most of the haematological and biochemical parameters including total and cholesterol fractions in plasma. In rats treated with SDF a significant increase of triglycerides was observed as compared to control group. By contrast in EDF rats significantly decreased triglycerides were detected. EDF orally administered to rats was safe and not treatment-related toxicity was detected. The results also suggest that EDF could protect against the increase of triglyceride concentrations in plasma. |
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Authors:
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Arturo Anadon; Maria Rosa Martinez-Larrañaga; Maria Aranzazu Martínez; Irma Ares; Eva Ramos; Pilar Gomez-Cortes; Manuela Juarez; Miguel Angel de la Fuente |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-17 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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