Document Detail


A 4-month, open-label study evaluating the efficacy of eflornithine 11.5% cream in the treatment of unwanted facial hair in women using TrichoScan.
MedLine Citation:
PMID:  18086592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eflornithine 11.5% cream is an effective treatment for unwanted facial hair (UFH) in women with the effect on facial hair growth starting to be seen from 1 month after treatment initiation. TrichoScan is a validated method of assessing hair length, thickness, density, and growth rate using contact skin microscopy. The study aimed to evaluate the efficacy of eflornithine cream in women with UFH, as assessed by TrichoScan. In this open-label, single-centre study, 25 women (aged 25-63 years) applied eflornithine 11.5% cream to the upper lip twice daily for 4 months. Hair density, mean and cumulative hair length, mean hair thickness and hair growth rate were assessed at baseline and Month 1, 2 and 4 using TrichoScan. Eflornithine cream significantly decreased hair density from baseline to Month 1 (- 11.4 hairs/cm2, p = 0.014), Month 2 (- 16.5 hairs/cm2, p = 0.013) and Month 4 (- 12.05 hairs/cm2, p = 0.05). In addition, cumulative hair length decreased from baseline to Month 1 (- 7.104 mm, p = 0.001), Month 2 (- 10.054 mm, p < 0.001) and Month 4 (- 8.061 mm, p = 0.001). There was also a significant decrease in hair growth rate. Mean hair thickness did not change significantly. Eflornithine 11.5% cream is an effective treatment for UFH in women with the effect on facial hair growth starting to be seen from 1 month after treatment initiation.
Authors:
Rolf Hoffmann
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-18
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  18     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-06-05     Revised Date:  2010-01-07    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Affiliation:
Dermaticum, Privatpraxis für Dermatologie, Kaiser-Joseph-Str. 262, 79098 Freiburg, Germany. rolf.hoffmann@dermaticum.de
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Dermoscopy
Eflornithine / administration & dosage*
Face*
Female
Hair Removal / methods*
Humans
Middle Aged
Ointment Bases
Chemical
Reg. No./Substance:
0/Ointment Bases; 70052-12-9/Eflornithine
Comments/Corrections
Comment In:
Eur J Dermatol. 2009 Nov-Dec;19(6):663; author reply 664   [PMID:  19819778 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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