Document Detail


4-Oxo-1,4-dihydropyridines as Selective CB2 Cannabinoid Receptor Ligands Part 2: Discovery of New Agonists Endowed with Protective Effect Against Experimental Colitis.
MedLine Citation:
PMID:  23017078     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Further to our earlier work on a the 4-oxo-1,4-dihydropyridine, we describe herein our strategy to get access to potent selective CB2 receptor agonists. Thus, we designed and synthesized twenty nine compounds, evaluated on both hCB1 and hCB2 cannabinoid receptors and assessed eleven of them in the TNBS-induced colitis model in mice. Compound 48 was found to be the most efficient of our series, exhibiting an exquisite protection against experimental colitis, superior to the one observed after treatment with Pentasa.
Authors:
Jamal El Bakali; Pauline Gilleron; Mathilde Body-Malapel; Roxane Mansouri; Giulio G Muccioli; Madjid Djouina; Amélie Barczyk; Fréderique Klupsch; Virginie Andrzejak; Emanuelle Lipka; Christophe Furman; Didier M Lambert; Philippe Chavatte; Pierre Desreumaux; Regis Millet
Related Documents :
11859098 - Receptor-facilitated antigen presentation requires the recruitment of b cell linker pro...
17307998 - Angiotensin ii mediates postischemic leukocyte-endothelial interactions: role of calcit...
8293568 - Integrin-mediated collagen gel contraction by cardiac fibroblasts. effects of angiotens...
10997688 - Role of galectin-3 as a receptor for advanced glycosylation end products.
11859098 - Receptor-facilitated antigen presentation requires the recruitment of b cell linker pro...
1398 - Effect of lumbar sympathetic blockade and chlorpromazine-induced adrenergic alpha-recep...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Functional conservation and divergence of BMP ligands in limb development and lipid homeostasis of h...
Next Document:  Deep mitochondrial introgression and hybridization among ecologically divergent vole species.