Document Detail

4-Oxo-1,4-dihydropyridines as Selective CB2 Cannabinoid Receptor Ligands Part 2: Discovery of New Agonists Endowed with Protective Effect Against Experimental Colitis.
MedLine Citation:
PMID:  23017078     Owner:  NLM     Status:  Publisher    
Further to our earlier work on a the 4-oxo-1,4-dihydropyridine, we describe herein our strategy to get access to potent selective CB2 receptor agonists. Thus, we designed and synthesized twenty nine compounds, evaluated on both hCB1 and hCB2 cannabinoid receptors and assessed eleven of them in the TNBS-induced colitis model in mice. Compound 48 was found to be the most efficient of our series, exhibiting an exquisite protection against experimental colitis, superior to the one observed after treatment with Pentasa.
Jamal El Bakali; Pauline Gilleron; Mathilde Body-Malapel; Roxane Mansouri; Giulio G Muccioli; Madjid Djouina; Amélie Barczyk; Fréderique Klupsch; Virginie Andrzejak; Emanuelle Lipka; Christophe Furman; Didier M Lambert; Philippe Chavatte; Pierre Desreumaux; Regis Millet
Related Documents :
7928878 - Angiotensin mediates stimulation of ventilation after vasopressin v1 receptor blockade.
11137438 - Angiotensin signaling and receptor types in teleost fish.
8166228 - Vasoconstrictive peptides induce endothelin-1 and prostanoids in human cerebromicrovasc...
10425188 - Increased vasoconstrictor response of the mouse lacking angiotensin ii type 2 receptor.
9988678 - Decorin is a biological ligand for the epidermal growth factor receptor.
25412688 - Incretin-based antidiabetic agents for the management of non-alcoholic fatty liver dise...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functional conservation and divergence of BMP ligands in limb development and lipid homeostasis of h...
Next Document:  Deep mitochondrial introgression and hybridization among ecologically divergent vole species.