| 4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis. | |
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MedLine Citation:
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PMID: 16270277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4-Hydroxynonenal (HNE) is by far the most investigated aldehydic end-product of oxidative breakdown of membrane n-6 polyunsaturated fatty acids. Its potential involvement in the pathogenesis of atherosclerosis has been corroborated by its consistent detection in both oxidized LDL and fibrotic plaque in humans. HNE has been shown to activate both macrophage and smooth muscle cells, i.e. the two key cell types in chronic inflammatory processes characterized by excessive fibrogenesis. By signalling to the nucleus, the aldehyde may up-regulate in these cells both expression and synthesis of monocyte chemotactic protein 1 (MCP-1) and transforming growth factor beta1 (TGFbeta1). Oxysterols, namely 27 carbon atoms oxidation products of cholesterol, are found in relatively high amount in LDL from hypercholesterolemic individuals and are consistently detectable in foam cells and necrotic core of human atherosclerotic lesion. As for HNE, the challenge of cells of the macrophage lineage with a mixture of oxysterols like that detectable in hypercholesterolemic individuals led to a marked overexpression of TGFbeta1 and MCP-1. Both HNE and oxysterols then appear to be candidates for a primary role in the progression of the atherosclerotic process. |
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Authors:
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Gabriella Leonarduzzi; Elena Chiarpotto; Fiorella Biasi; Giuseppe Poli |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 49 ISSN: 1613-4125 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-09 Completed Date: 2006-02-16 Revised Date: 2007-03-22 |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1044-9 Citation Subset: IM |
Affiliation:
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Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
/
analysis,
chemistry,
metabolism*,
pharmacology Animals Apoptosis / drug effects Atherosclerosis / metabolism* Cell Nucleus / metabolism Cholesterol / metabolism* Gene Expression / drug effects Humans Inflammation Lipoproteins, LDL / chemistry Macrophage Activation / drug effects Molecular Structure Myocytes, Smooth Muscle / drug effects, physiology Oxidation-Reduction Signal Transduction Sterols / chemistry, pharmacology Transcription Factors / physiology |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Lipoproteins, LDL; 0/Sterols; 0/Transcription Factors; 0/oxidized low density lipoprotein; 29343-52-0/4-hydroxy-2-nonenal; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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