Document Detail

4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.
MedLine Citation:
PMID:  16270277     Owner:  NLM     Status:  MEDLINE    
4-Hydroxynonenal (HNE) is by far the most investigated aldehydic end-product of oxidative breakdown of membrane n-6 polyunsaturated fatty acids. Its potential involvement in the pathogenesis of atherosclerosis has been corroborated by its consistent detection in both oxidized LDL and fibrotic plaque in humans. HNE has been shown to activate both macrophage and smooth muscle cells, i.e. the two key cell types in chronic inflammatory processes characterized by excessive fibrogenesis. By signalling to the nucleus, the aldehyde may up-regulate in these cells both expression and synthesis of monocyte chemotactic protein 1 (MCP-1) and transforming growth factor beta1 (TGFbeta1). Oxysterols, namely 27 carbon atoms oxidation products of cholesterol, are found in relatively high amount in LDL from hypercholesterolemic individuals and are consistently detectable in foam cells and necrotic core of human atherosclerotic lesion. As for HNE, the challenge of cells of the macrophage lineage with a mixture of oxysterols like that detectable in hypercholesterolemic individuals led to a marked overexpression of TGFbeta1 and MCP-1. Both HNE and oxysterols then appear to be candidates for a primary role in the progression of the atherosclerotic process.
Gabriella Leonarduzzi; Elena Chiarpotto; Fiorella Biasi; Giuseppe Poli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  49     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-09     Completed Date:  2006-02-16     Revised Date:  2007-03-22    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1044-9     Citation Subset:  IM    
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
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MeSH Terms
Aldehydes / analysis,  chemistry,  metabolism*,  pharmacology
Apoptosis / drug effects
Atherosclerosis / metabolism*
Cell Nucleus / metabolism
Cholesterol / metabolism*
Gene Expression / drug effects
Lipoproteins, LDL / chemistry
Macrophage Activation / drug effects
Molecular Structure
Myocytes, Smooth Muscle / drug effects,  physiology
Signal Transduction
Sterols / chemistry,  pharmacology
Transcription Factors / physiology
Reg. No./Substance:
0/Aldehydes; 0/Lipoproteins, LDL; 0/Sterols; 0/Transcription Factors; 0/oxidized low density lipoprotein; 29343-52-0/4-hydroxy-2-nonenal; 57-88-5/Cholesterol

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