Document Detail

4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications.
MedLine Citation:
PMID:  11229439     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen intermediates (ROI) and other pro-oxidant agents are known to elicit, in vivo and in vitro, oxidative decomposition of omega-3 and omega-6 polyunsaturated fatty acids of membrane phospholipids (i.e, lipid peroxidation). This leads to the formation of a complex mixture of aldehydic end-products, including malonyldialdehyde (MDA), 4-hydroxy-2,3-nonenal (HNE), and other 4-hydroxy-2,3-alkenals (HAKs) of different chain length. These aldehydic molecules have been considered originally as ultimate mediators of toxic effects elicited by oxidative stress occurring in biological material. Experimental and clinical evidence coming from different laboratories now suggests that HNE and HAKs can also act as bioactive molecules in either physiological and pathological conditions. These aldehydic compounds can affect and modulate, at very low and nontoxic concentrations, several cell functions, including signal transduction, gene expression, cell proliferation, and, more generally, the response of the target cell(s). In this review article, we would like to offer an up-to-date review on this particular aspect of oxidative stress--dependent modulation of cellular functions-as well as to offer comments on the related pathophysiological implications, with special reference to human conditions of disease.
M Parola; G Bellomo; G Robino; G Barrera; M U Dianzani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  1     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  1999  
Date Detail:
Created Date:  2001-03-02     Completed Date:  2001-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-84     Citation Subset:  IM    
Dipartimento di Medicina e Oncologia Sperimentale, Università degli Studi di Torino, Italy.
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MeSH Terms
Aldehydes / chemistry,  metabolism*,  toxicity
Arteriosclerosis / chemically induced,  physiopathology
Chemotactic Factors / physiology
Chronic Disease
Inflammation / physiopathology
Liver Diseases / physiopathology
Nervous System Diseases / physiopathology
Oxidative Stress
Proteins / metabolism
Reperfusion Injury / physiopathology
Signal Transduction*
Reg. No./Substance:
0/Aldehydes; 0/Chemotactic Factors; 0/Proteins; 29343-52-0/4-hydroxy-2-nonenal

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