| 3T deep gray matter T2 hypointensity correlates with disability over time in stable relapsing-remitting multiple sclerosis: a 3-year pilot study. | |
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MedLine Citation:
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PMID: 20708201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormally decreased deep gray matter (GM) signal intensity on T2-weighted MRI (T2 hypointensity) is associated with brain atrophy and disability progression in patients with multiple sclerosis (MS) and is believed to represent excessive iron deposition. We investigated the time course of deep GM T2 hypointensity and its relationship with disability at 3T in 8 stable relapsing-remitting (RR) MS patients treated with minocycline over 3years. MRI and disability measurements were compared at baseline, 6, 12, 24, and 36months. Grand mean deep GM T2 hypointensity was negatively correlated with EDSS over time (r=-0.94, P=0.02). This correlation was strongest in the head of caudate (r=-0.95, P=0.01) and putamen (r=-0.89, P=0.04). Additionally, baseline grand mean deep GM T2 hypointensity appears to predict third year EDSS (r=-0.72, P=0.04). These results suggest that iron associated deep GM injury correlates with patient disability in stable RRMS. Measurements of deep GM T2 hypointensity at high field MRI may prove to be useful in monitoring individuals with MS. Further studies are required to confirm these results in a large sample and to determine if T2 hypointensity changes in clinically active MS patients. |
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Authors:
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Y Zhang; L M Metz; V W Yong; J R Mitchell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-12 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 297 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 76-81 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Clinical Neurosciences, University of Calgary, Canada. yunyzhan@ucalgary.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anti-Bacterial Agents / therapeutic use Atrophy / pathology Brain / pathology* Disability Evaluation Disabled Persons* Female Humans Longitudinal Studies Magnetic Resonance Imaging / methods Male Middle Aged Minocycline / therapeutic use Multiple Sclerosis, Relapsing-Remitting / complications*, drug therapy, pathology* Nerve Fibers, Unmyelinated / pathology* Pilot Projects Severity of Illness Index Statistics as Topic Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 10118-90-8/Minocycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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