Document Detail

[3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors.
MedLine Citation:
PMID:  3569426     Owner:  NLM     Status:  MEDLINE    
Nicotinic agonists (nicotine, 1,1-dimethyl-4-phenylpiperazinium (DMPP) increased [3H]acetylcholine release when the pre-exposure time was short (20 s). This effect was antagonized by pretreatment with d-tubocurarine (d-TC), which indicates a receptor-mediated effect. After a longer pre-exposure time (3 min) 10 microM nicotine significantly decreased the evoked [3H]acetylcholine release, probably because desensitization of the nicotine autoreceptors had abolished the nicotinic autofacilitation of transmitter release.
I Wessler; B Scheuer; H Kilbinger
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  135     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / metabolism*
Dimethylphenylpiperazinium Iodide / pharmacology
Nicotine / metabolism
Phrenic Nerve / metabolism*
Rats, Inbred Strains
Receptors, Nicotinic / drug effects,  metabolism*
Reg. No./Substance:
0/Receptors, Nicotinic; 51-84-3/Acetylcholine; 54-11-5/Nicotine; 54-77-3/Dimethylphenylpiperazinium Iodide

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