Document Detail

[3H]Ouabain binding and 86 rubidium uptake during the dimethyl sulfoxide-induced differentiation of human promyelocytic leukemia HL-60 cells.
MedLine Citation:
PMID:  6092144     Owner:  NLM     Status:  MEDLINE    
When HL-60 cells were induced to differentiate into granulocyte-like cells by culture in the presence of 1.3% dimethyl sulfoxide, an increase in the rate of ouabain-sensitive 86Rb transport was observed during the first 6 h followed by a constant decrease which became stable on day 4 at about 40% of control level. By contrast, the number of ouabain binding sites remained constant during the first 24 h then decreased with the same kinetics as that of the 86Rb transport rate. These results suggest that alterations in ionic fluxes, through activation of the sodium pump, are part of the early events resulting in HL-60 cell differentiation.
A Ladoux; B Geny; N Marrec; J P Abita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  176     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-10     Completed Date:  1984-12-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
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MeSH Terms
Binding Sites
Cell Differentiation / drug effects
Cell Line
Dimethyl Sulfoxide / pharmacology*
Leukemia, Myeloid, Acute / metabolism*
Ouabain / metabolism*
Rubidium / metabolism*
Sodium-Potassium-Exchanging ATPase / metabolism
Time Factors
Reg. No./Substance:
630-60-4/Ouabain; 67-68-5/Dimethyl Sulfoxide; 7440-17-7/Rubidium; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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