Document Detail

3H-etorphine levels in CNS of tolerant and non-tolerant rats.
MedLine Citation:
PMID:  560034     Owner:  NLM     Status:  MEDLINE    
Rats were rendered tolerant to etorphine by administering it daily for 5 days at doses of either 10 microgram/kg i.v. or 5 microgram/kg s.c..3H-etorphine was then injected to tolerant and non-tolerant rats; after 15 min their brain and spinal cord were removed for 3H-etorphine assay. Tolerant rats had lower 3H-etorphine levels in both tissues than control rats.
A Luini; L Manara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  17     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism
Catatonia / chemically induced
Central Nervous System / metabolism*
Drug Tolerance
Etorphine / metabolism*,  pharmacology
Morphinans / metabolism*
Postural Balance / drug effects
Spinal Cord / metabolism
Reg. No./Substance:
0/Morphinans; 14521-96-1/Etorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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