Document Detail


The 3D vascular status of the follicle after HCG administration is qualitatively rather than quantitatively associated with its reproductive competence.
MedLine Citation:
PMID:  17179201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The objective of this study was to determine whether the vascular status of a single pre-ovulatory follicle is associated quantitatively and/or qualitatively with its reproductive competence. METHODS: We studied 61 monofollicular IVF-embryo transfer cycles. Just before single oocyte retrieval, follicle vascularization was detected by transvaginal power-Doppler, 3-dimensionally reconstructed, and analysed quantitatively by coloured/gray voxel ratio [vascularization index (VI)] and qualitatively by blood cell displacement [flow index (FI)] calculation. Cycles were sorted in two sets of two groups: low VI (<or=8%, n = 44) and high VI (>8%, n = 17); low FI (<or=30, n = 22) and high FI (>30, n = 39). RESULTS: Patients' characteristics, fertilization rates, and embryo morphology were comparable in all groups. In contrast, clinical pregnancy rates/oocyte retrieval (4% versus 33%, P < 0.009) and implantation rates (11% versus 50%, P < 0.04) were markedly poorer in the low as compared to the high FI groups, respectively, but remained similar between the low and the high VI groups (22% versus 23% and 38% versus 44%, respectively). CONCLUSIONS: A qualitative (FI) rather than quantitative (VI) relationship exists between vascular status and functional quality of the follicle after HCG administration.
Authors:
Daniel H Mendez Lozano; Nelly Frydman; Jean M Levaillant; Stéphanie Fay; René Frydman; Renato Fanchin
Publication Detail:
Type:  Journal Article     Date:  2006-12-19
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  22     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1095-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology and Reproductive Medicine, INSERM Unit 782, Clamart, Université Paris XI, Le Kremlin-Bicêtre, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / administration & dosage*
Embryo Implantation
Embryo Transfer
Female
Fertilization in Vitro
Hormones / blood
Humans
Infertility, Female / therapy
Oocytes / metabolism
Ovary / metabolism
Pregnancy
Pregnancy Rate
Prospective Studies
Reproduction*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary ...
Next Document:  A B23-interacting sequence as a tool to visualize protein interactions in a cellular context.