| 3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells. | |
| | |
MedLine Citation:
|
PMID: 20810259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent research using an innovative 3D quantitative FISH approach of nuclear remodelling associated with the transition from mononuclear Hodgkin to diagnostic multinuclear Reed-Sternberg cells revealed profound changes in the 3D nuclear organization of telomeres. Analogous 3D telomere dynamics were identified in Hodgkin's lymphoma derived cell-lines and diagnostic patient biopsies. These changes were observed in both, EBV positive and EBV-negative Hodgkin's lymphoma and independent of the age of the patients at presentation. Compared to mononuclear Hodgkin cells, multinuclear Reed-Sternberg cells are characterized by a highly significant increase of telomere aggregates, often composed of very short telomeres, telomere shortening and loss. RS-cells with telomere free "ghost" nuclei are regularly observed. The telomere protecting shelterin complex appears to be disrupted and deregulation of DNA-repair mechanisms is observed. Our findings are consistent with the hypothesis that distinct 3D telomere changes and shelterin disruption represent a common pathogenetic denominator in the generation of Reed-Sternberg cells. |
| | |
Authors:
|
Hans Knecht; Silke Brüderlein; Sabine Mai; Peter Möller; Bassem Sawan |
Related Documents
:
|
1559229 - Immortalization of carcinogen-treated syrian hamster embryo cells occurs indirectly via... 1244399 - Calendar life-span versus fission life-span of paramecium aurelia. 21209109 - Complex cell cycle abnormalities caused by human t-lymphotropic virus type 1 tax. 3258879 - Cationization of protein antigens. iv. increased antigen uptake by antigen-presenting c... 12640679 - Differential effects between amphoterin and advanced glycation end products on colon ca... 17785819 - The role of b cells in the development of cd4 effector t cells during a polarized th2 i... 20981829 - Lef1 controls patterning and proliferation in the posterior lateral line system of zebr... 7770529 - Polysaccharide composition of unlignified cell walls of pineapple [ananas comosus (l.) ... 8133779 - Response of ataxia telangiectasia cells to restriction endonuclease induced dna double-... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-06 |
Journal Detail:
|
Title: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Volume: 192 ISSN: 1618-0402 ISO Abbreviation: Ann. Anat. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100963897 Medline TA: Ann Anat Country: Germany |
Other Details:
|
Languages: eng Pagination: 302-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Division d'Hématologie, CHUS, Université de Sherbrooke, Sherbrooke, Québec, Canada. hans.knecht@usherbrooke.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Nucleus
/
genetics,
ultrastructure Hodgkin Disease / genetics, pathology* Humans Imaging, Three-Dimensional Reed-Sternberg Cells / pathology, ultrastructure* Telomere / ultrastructure* |
| Grant Support | |
ID/Acronym/Agency:
|
//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression and activation of matrix metalloproteinase-9 and NADPH oxidase in tissues and plasma of e...
Next Document: The role of Sp1 and Sp3 in normal and cancer cell biology.