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3D myocardial T(1) mapping at 3T using variable flip angle method: Pilot study.
MedLine Citation:
PMID:  23440632     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Myocardial T(1) mapping is an emerging technique that could improve cardiovascular magnetic resonance diagnostic accuracy. In this study, a variable flip angle approach with B(1) correction is proposed at 3T on the myocardium, employing standard 3D spoiled fast gradient echo and echo planar imaging sequences. METHODS: The method was tested on phantoms to determine the set of standard 3D spoiled fast gradient echo angles adapted to myocardial T(1) measurements and was compared to the inversion-recovery spin-echo reference T(1) method. Seven volunteers underwent magnetic imaging resonance to acquire myocardial T(1) maps and T(1) values of the human heart. RESULTS: This original method demonstrated good reproducibility in phantoms and a significant correlation between variable flip angle T(1) values and reference inversion-recovery spin-echo T(1) values. It yielded myocardial T(1) values consistent with expected T(1) and an increasing homogenization of myocardial segments owing to B(1) correction. The mean myocardial T(1) value was 1341 ± 42 ms. CONCLUSION: Myocardial 3D T(1) mapping using the variable flip angle approach can potentially be useful for evaluating fibrosis on the entire myocardium using a standard clinical sequence. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Authors:
Hélène Clique; Hai-Ling Margaret Cheng; Pierre-Yves Marie; Jacques Felblinger; Marine Beaumont
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-25
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Université de Lorraine, IADI, UMR S 947, Nancy, France; INSERM, IADI, U947, Nancy, France.
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