Document Detail


3D fusion of intravascular ultrasound and coronary computed tomography for in-vivo wall shear stress analysis: a feasibility study.
MedLine Citation:
PMID:  19946749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wall shear stress, the force per area acting on the lumen wall due to the blood flow, is an important biomechanical parameter in the localization and progression of atherosclerosis. To calculate shear stress and relate it to atherosclerosis, a 3D description of the lumen and vessel wall is required. We present a framework to obtain the 3D reconstruction of human coronary arteries by the fusion of intravascular ultrasound (IVUS) and coronary computed tomography angiography (CT). We imaged 23 patients with IVUS and CT. The images from both modalities were registered for 35 arteries, using bifurcations as landmarks. The IVUS images together with IVUS derived lumen and wall contours were positioned on the 3D centerline, which was derived from CT. The resulting 3D lumen and wall contours were transformed to a surface for calculation of shear stress and plaque thickness. We applied variations in selection of landmarks and investigated whether these variations influenced the relation between shear stress and plaque thickness. Fusion was successfully achieved in 31 of the 35 arteries. The average length of the fused segments was 36.4 ± 15.7 mm. The length in IVUS and CT of the fused parts correlated excellently (R (2) = 0.98). Both for a mildly diseased and a very diseased coronary artery, shear stress was calculated and related to plaque thickness. Variations in the selection of the landmarks for these two arteries did not affect the relationship between shear stress and plaque thickness. This new framework can therefore successfully be applied for shear stress analysis in human coronary arteries.
Authors:
Alina G van der Giessen; Michiel Schaap; Frank J H Gijsen; Harald C Groen; Theo van Walsum; Nico R Mollet; Jouke Dijkstra; Frans N van de Vosse; Wiro J Niessen; Pim J de Feyter; Antonius F W van der Steen; Jolanda J Wentzel
Related Documents :
22249619 - Saccular intracranial aneurysm: pathology and mechanisms.
11502699 - Decreased coagulability has no clinically relevant effect on atherogenesis: observation...
7381519 - Age changes at cerebral artery bifurcations and the pathogenesis of berry aneurysms.
20846449 - Theoretical generalization of normal and sick coronary arteries with fractal dimensions...
10794169 - Pre-eclampsia associated alterations of the elastic fibre system in umbilical cord vess...
21815299 - Rediscovering the third coronary artery.
451879 - Fibromuscular dysplasia of the external iliac arteries: surgical treatment by graduated...
15714379 - Celiac artery aneurysm embolization by coil occlusion.
1312469 - Technetium-99m diethylene triamine penta-acetic acid and dimercaptosuccinic acid in the...
Publication Detail:
Type:  Journal Article     Date:  2009-11-28
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  26     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-96     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Erasmus MC, Biomechanics Laboratory Ee2322, Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Coronary Angiography / methods*
Coronary Artery Disease / physiopathology,  radiography*,  ultrasonography*
Coronary Circulation
Feasibility Studies
Humans
Imaging, Three-Dimensional*
Netherlands
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted*
Reproducibility of Results
Retrospective Studies
Stress, Mechanical
Tomography, X-Ray Computed*
Ultrasonography, Interventional*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people.
Next Document:  Comparison of 3D-diffusion-prepared segmented steady-state free precession and 2D fast spin echo ima...