Document Detail


A 3D fiber model of the human brainstem.
MedLine Citation:
PMID:  12453507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new neuroanatomic approach to evaluate the fiber orientation in gross histological sections of the human brain was developed. Serial sections of a human brainstem were used to derive fiber orientation maps by analysis of polarized light sequences of these sections. Fiber inclination maps visualize angles of inclination, and fiber direction maps show angles of direction. These angles define vectors which can be visualized as RGB-colors. The serial sections were aligned to each other using the minimized Euclidian distance as fit criterion. In the 3D data set of the human brainstem the major fiber tracts were segmented, and three-dimensional models of these fiber tracts were generated. The presented results demonstrate that two kinds of fiber atlases are feasible: a fiber orientation atlas representing a vector in each voxel, which shows the nerve fiber orientation, and a volume-based atlas representing the major fiber tracts. These models can be used for the evaluation of diffusion tensor data as well as for neurosurgical planning.
Authors:
Hubertus Axer; Matthias Leunert; Malte Mürköster; David Grässel; Luiza Larsen; Lewis D Griffin; Diedrich Graf v Keyserlingk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society     Volume:  26     ISSN:  0895-6111     ISO Abbreviation:  Comput Med Imaging Graph     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-03-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8806104     Medline TA:  Comput Med Imaging Graph     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Affiliation:
Department of Neurology, Friedrich-Schiller-University Jena, Philosophenweg 3, D-07740, Jena, Germany. hubertus.axer@med.uni-jena.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain Stem / anatomy & histology*
Female
Humans
Imaging, Three-Dimensional / methods*
Models, Anatomic*
Nerve Fibers / ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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