| 3D blood flow characteristics in the carotid artery bifurcation assessed by flow-sensitive 4D MRI at 3T. | |
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MedLine Citation:
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PMID: 19097219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine three-dimensional (3D) blood flow patterns in the carotid bifurcation, 10 healthy volunteers and nine patients with internal carotid artery (ICA) stenosis > or =50% were examined by flow-sensitive 4D MRI at 3T. Absolute and mean blood velocities, pulsatility index (PI), and resistance index (RI) were measured in the common carotid arteries (CCAs) by duplex sonography (DS) and compared with flow-sensitive 4D MRI. Furthermore, 3D MRI blood flow patterns in the carotid bifurcation of volunteers and patients before and after recanalization were graded by two independent readers. Blood flow velocities measured by MRI were 31-39% lower than in DS. However, PI and RI differed by only 13-16%. Rating of 3D flow characteristics in the ICA revealed consistent patterns for filling and helical flow in volunteers. In patients with ICA stenosis, 3D blood flow visualization was successfully employed to detect markedly altered filling and helical flow patterns (forward-moving spiral flow) in the ICA bulb and to evaluate the effect of revascularization, which restored filling and helical flow. Our results demonstrate the feasibility of flow-sensitive 4D MRI for the quantification and 3D visualization of physiological and pathological flow patterns in the carotid artery bifurcation. |
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Authors:
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A Harloff; F Albrecht; J Spreer; A F Stalder; J Bock; A Frydrychowicz; J Schöllhorn; A Hetzel; M Schumacher; J Hennig; M Markl |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 61 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-24 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 65-74 Citation Subset: IM |
Affiliation:
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Department of Neurology and Clinical Neurophysiology, University of Freiburg, Freiburg, Germany. andreas.harloff@uniklinik-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Blood Flow Velocity* Carotid Arteries / physiopathology* Carotid Stenosis / diagnosis*, physiopathology* Feasibility Studies Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods Imaging, Three-Dimensional / methods* Magnetic Resonance Imaging, Cine / methods* Male Reproducibility of Results Rheology / methods* Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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