Document Detail


3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.
MedLine Citation:
PMID:  23765688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions.
Authors:
Martin E Kolewe; Hyoungshin Park; Caprice Gray; Xiaofeng Ye; Robert Langer; Lisa E Freed
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-06-14
Journal Detail:
Title:  Advanced materials (Deerfield Beach, Fla.)     Volume:  25     ISSN:  1521-4095     ISO Abbreviation:  Adv. Mater. Weinheim     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-20     Completed Date:  2014-03-10     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9885358     Medline TA:  Adv Mater     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  4459-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Line
Decanoates / chemistry*
Glycerol / analogs & derivatives*,  chemistry
Mice
Microtechnology
Myoblasts / cytology*
Myocardium / cytology*
Polymers / chemistry*
Porosity
Rats
Tissue Engineering / methods*
Tissue Scaffolds / chemistry*
Grant Support
ID/Acronym/Agency:
1-R01-HL107503/HL/NHLBI NIH HHS; R01 HL107503/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Decanoates; 0/Polymers; 0/elastomeric; 0/poly(glycerol-sebacate); PDC6A3C0OX/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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