Document Detail


3D MRI of impaired hyperpolarized (129) Xe uptake in a rat model of pulmonary fibrosis.
MedLine Citation:
PMID:  24816478     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A variety of pulmonary pathologies, in particular interstitial lung diseases, are characterized by thickening of the pulmonary blood-gas barrier, and this thickening results in reduced gas exchange. Such diffusive impairment is challenging to quantify spatially, because the distributions of the metabolically relevant gases (CO2 and O2 ) cannot be detected directly within the lungs. Hyperpolarized (HP) (129) Xe is a promising surrogate for these metabolic gases, because MR spectroscopy and imaging allow gaseous alveolar (129) Xe to be detected separately from (129) Xe dissolved in the red blood cells (RBCs) and the adjacent tissues, which comprise blood plasma and lung interstitium. Because (129) Xe reaches the RBCs by diffusing across the same barrier tissues (blood plasma and interstitium) as O2 , barrier thickening will delay (129) Xe transit and, thus, reduce RBC-specific (129) Xe MR signal. Here we have exploited these properties to generate 3D, MR images of (129) Xe uptake by the RBCs in two groups of rats. In the experimental group, unilateral fibrotic injury was generated prior to imaging by instilling bleomycin into one lung. In the control group, a unilateral sham instillation of saline was performed. Uptake of (129) Xe by the RBCs, quantified as the fraction of RBC signal relative to total dissolved (129) Xe signal, was significantly reduced (P = 0.03) in the injured lungs of bleomycin-treated animals. In contrast, no significant difference (P = 0.56) was observed between the saline-treated and untreated lungs of control animals. Together, these results indicate that 3D MRI of HP (129) Xe dissolved in the pulmonary tissues can provide useful biomarkers of impaired diffusive gas exchange resulting from fibrotic thickening. Copyright © 2014 John Wiley & Sons, Ltd.
Authors:
Zackary I Cleveland; Rohan S Virgincar; Yi Qi; Scott H Robertson; Simone Degan; Bastiaan Driehuys
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-12
Journal Detail:
Title:  NMR in biomedicine     Volume:  -     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 John Wiley & Sons, Ltd.
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