| 3D and 2D delayed-enhancement magnetic resonance imaging for detection of myocardial infarction: preclinical and clinical results. | |
| | |
MedLine Citation:
|
PMID: 17574129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: The purpose was to verify whether myocardial viability can be detected by a delayed enhancement magnetic resonance imaging (MRI) approach using a rapid three-dimensional inversion-recovery fast low-angle shot (3D IR-FLASH) sequence in a preclinical and clinical setting. MATERIALS AND METHODS: Nonreperfused myocardial infarctions were induced in eight minipigs. Both the pigs and 15 patients with suspected myocardial infarction underwent MRI using a rapid 3D IR-FLASH sequence and a two-dimensional IR-FLASH sequence as the reference standard. RESULTS: In the pigs, a total of 52 segments with myocardial infarction were identified with both sequences and there was good agreement in transmurality of 99.5%. The infarction volume determined with the 3D IR-FLASH in the animal study (2.4 +/- 1.5 cm(3)) showed a good correlation with the histomorphometrically determined volume using triphenyltetrazolium chloride (2.3 +/- 1.2 cm(3), r = 0.98, P < .001) and the two-dimensional IR-FLASH sequence (2.3 +/- 1.4 cm(3), r = 0.99, P < .001). Eleven of 15 patients were found to have myocardial infarction in 37 myocardial segments with both sequences and there was a good agreement in transmurality of 98.8%. There was also a good correlation in the clinical study between the 3D and 2D sequences (6.9 +/- 6.7 cm(3) vs. 6.8 +/- 6.5 cm(3), r = 0.98, P < .001). In Bland-Altman analysis there was no significant under- or overestimation of the myocardial infarction volume using the 3D IR-FLASH sequence in comparison to the two-dimensional reference standard in both the preclinical and clinical study. The contrast-to-noise ratios were not significantly different between 3D and 2D sequences in the animal (34.7 +/- 1.5 vs. 33.8 +/- 2.6; P = .51) and clinical study (31.4 +/- 12.5 vs. 36.7 +/- 11.5; P = .31). The breathhold time for the 3D IR-FLASH sequence in the clinical study (20.4 +/- 2.2 s) was significantly shorter than that of the 2D IR-FLASH sequence (190.1 +/- 20.8 s, P < .001). CONCLUSIONS: The rapid 3D IR-FLASH sequence detects myocardial infarction with high accuracy and allows a relevant reduction in acquisition time. |
| | |
Authors:
|
Daniel Peukert; Michael Laule; Matthias Taupitz; Nicola Kaufels; Bernd Hamm; Marc Dewey |
Related Documents
:
|
17938179 - Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caus... 15210399 - Anticoagulation with low-molecular-weight heparin in patients with heart diseases. 10853939 - Correlation of clinical and neuroradiological findings in down-gaze palsy. 7724179 - Sensitivity of laser flare photometry to monitor inflammation in uveitis of the posteri... 16724969 - Percutaneous left and right heart catheterization in fully anticoagulated patients util... 9562269 - Aphagia due to pharyngeal constrictor paresis from acute lateral medullary infarction. 3958339 - Reproducibility of arrhythmia induction with intracardiac electrophysiologic testing: p... 8197969 - Conjoint use of mm and mb creatine kinase isoforms in detection of coronary recanalizat... 3894249 - Echocardiographic evaluation after blunt trauma of the chest. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Academic radiology Volume: 14 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-06-18 Completed Date: 2007-08-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 788-94 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Charité, Humboldt Universität zu Berlin, Institut für Radiologie, Charitéplatz 1, 10117 Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Animals Chronic Disease Contrast Media / administration & dosage Female Gadolinium DTPA / diagnostic use Heterocyclic Compounds / diagnostic use Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods Imaging, Three-Dimensional / methods* Magnetic Resonance Imaging / methods* Male Myocardial Infarction / diagnosis* Organometallic Compounds / diagnostic use Predictive Value of Tests Reference Standards Reproducibility of Results Sensitivity and Specificity Swine Swine, Miniature Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 80529-93-7/Gadolinium DTPA; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High resolution multidetector CT-aided tissue analysis and quantification of lung fibrosis.
Next Document: Gain in signal-to-noise for first-pass contrast-enhanced abdominal MR angiography at 3 Tesla over st...