| 3,5-diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. | |
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MedLine Citation:
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PMID: 22217997 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recently, it was demonstrated that 3,5-diiodo-L-thyronine (T2) stimulates the resting metabolic rate (RMR), and reduces body-weight gain of rats receiving a high-fat diet. The aim of this study is to examine the effects of chronic T2 administration on basal metabolic rate and body weight in humans. Two euthyroid subjects volunteered to undergo T2 administration. Body weight, body mass index, blood pressure, heart rate, electrocardiogram, thyroid and liver ultrasonography, glycemia, total cholesterol, triglycerides, free T3 (FT3), free T4 (FT4), T2, thyroid stimulating hormone (TSH) and RMR were evaluated at baseline and at the end of treatment. RMR increased significantly in each subject. After continuing the T2 treatment for a further 3 weeks (at 300 mcg/day), body weight was reduced significantly (p<0.05) (about 4 percent), while the serum levels of FT3, FT4 and TSH, were unchanged. No side effects were observed at the cardiac level in either subject. No significant change was observed in the same subjects taking placebo. |
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Authors:
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A Antonelli; P Fallahi; S M Ferrari; A Di Domenicantonio; M Moreno; A Lanni; F Goglia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biological regulators and homeostatic agents Volume: 25 ISSN: 0393-974X ISO Abbreviation: J. Biol. Regul. Homeost. Agents Publication Date: 2011 Oct-Dec |
Date Detail:
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Created Date: 2012-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809253 Medline TA: J Biol Regul Homeost Agents Country: Italy |
Other Details:
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Languages: eng Pagination: 655-60 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Pisa, Pisa, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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