Document Detail

3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores.
MedLine Citation:
PMID:  20944788     Owner:  NLM     Status:  In-Data-Review    
Recently, we described a 3.4-kb mitochondrial genome deletion having significance for identifying malignant and benign prostate tissues (p < 0.001). This biomarker was also present in normal appearing tissue, in close proximity to a tumour indicating a "field effect." In the present study, we report 4 cases (3 malignant, 1 benign) which suggest that this field effect may occur before tumourigenesis; this effect may also identify the presence of a small tumour focus/foci, which are difficult to detect with single or multiple biopsy procedures.
Brian Reguly; John P Jakupciak; Ryan L Parr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Urological Association journal = Journal de l'Association des urologues du Canada     Volume:  4     ISSN:  1911-6470     ISO Abbreviation:  Can Urol Assoc J     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312644     Medline TA:  Can Urol Assoc J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E118-22     Citation Subset:  -    
Genesis Genomics Inc., Thunder Bay, ON;
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