Document Detail

3',4'-Dihydroxyflavonol reduces vascular contraction through Ca(2+) desensitization in permeabilized rat mesenteric artery.
MedLine Citation:
PMID:  21993847     Owner:  NLM     Status:  Publisher    
3',4'-Dihydroxyflavonol (DiOHF) exerts endothelium-independent relaxation in rat aortic rings. In this study, we hypothesized that DiOHF reduces vascular contraction through Ca(2+) desensitization in permeabilized third-order branches of rat mesenteric arteries. The third-order branches of rat mesenteric arteries were permeabilized with β-escin and subjected to tension measurement. Cumulative addition of phenylephrine (0.3-30 μM) produced concentration-dependent vascular contraction of endothelium-intact and endothelium-denuded arterial rings, which were inhibited by pretreatment with DiOHF (10, 30, or 100 μM). In addition, DiOHF dose-dependently decreased vascular contractions induced by 3.0 μM phenylephrine. β-Escin-permeabilized third-order branches of mesenteric arteries were contracted with Ca(2+), NaF, or guanosine-5'-(γ-thio)triphosphate (GTPγS) 30 min after pretreatment with DiOHF or vehicle. Pretreatment with DiOHF for 30 min inhibited vascular contraction induced by cumulative additions of Ca(2+) (pCa 9.0-6.0) or NaF (4.0-16.0 mM) in permeabilized arterial rings. Cumulative addition of DiOHF also reduced vascular contraction induced by Ca(2+)-controlled solution of pCa 6.0, 16.0 mM NaF, or 100 μM GTPγS in permeabilized arterial rings. DiOHF inhibited the increase in vascular tension provoked by calyculin A, even though it did not affect vascular tension already produced by calyculin A. DiOHF accelerated the relaxation induced by rapidly lowering Ca(2+). DiOHF reduced vascular contraction through Ca(2+) desensitization in permeabilized third-order branches of rat mesenteric arteries. These results suggest that DiOHF may have a therapeutic potential in the treatment of cardiovascular diseases.
Hye Young Kim; Young Mi Seok; Owen L Woodman; Spencer J Williams; In Kyeom Kim
Related Documents :
6215897 - Flow in coronary artery bypass grafts to totally and partially occluded left anterior d...
634467 - Occlusion of the intradural vertebrobasilar artery.
6691087 - Catheter-directed low dose streptokinase infusion: a preliminary experience.
2055667 - Effect of coronary arterial occlusion on vagal control of heart rate.
20676587 - Rosiglitazone and vascular injury in hypercholesterolemic rabbits: neointimal formation...
24950567 - Pseudoaneurysm of the right hepatic artery and bile duct necrosis as a complication of ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-14
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  -     ISSN:  1432-1912     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pharmacology, Kyungpook National University School of Medicine, 101 Dongin-2-Ga, Daegu, 700-422, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effective use of physician extenders in an outpatient otolaryngology setting.
Next Document:  IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.