| 31P-nuclear magnetic resonance evidence of abnormal skeletal muscle metabolism in patients with chronic lung disease and congestive heart failure. | |
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MedLine Citation:
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PMID: 1559580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of 31P-nuclear magnetic resonance (NMR) has enabled direct and non-invasive measurements of muscle metabolism. Serial measurements of the phosphocreatine/inorganic phosphate (PCr/Pi) ratio, which is closely related to the adenosine triphosphate/adenosine diphosphate (ATP/ADP) ratio and pH during and after forearm exercise were performed in 11 patients with chronic lung disease (CLD), nine patients with chronic heart failure (CHF) and eight control subjects. As compared with control subjects, the PCr/Pi ratio in the patients with CLD or CHF was lower during the recovery period and significantly lower at three and 4 min exercise. The pH values after exercise were lower in patients with CLD or CHF compared to control subjects. The PCr/Pi ratio at 4 min after exercise in the patients with CLD or CHF did not correlate with parameters of cardiac function or arterial and mixed venous oxygen tension. The arterial oxygen content and output in patients with CLD and CHF were significantly lower than that of control subjects. Nutritional parameters were not statistically different among the three groups. These observations suggest that metabolic abnormalities may be present in the skeletal muscles of patients with CLD and CHF that are not due to under-nutrition. These may result from reduced arterial oxygen output and, partially, from physical detraining. |
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Authors:
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H Tada; H Kato; T Misawa; F Sasaki; S Hayashi; H Takahashi; Y Kutsumi; T Ishizaki; T Nakai; S Miyabo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 5 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-05-13 Completed Date: 1992-05-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 163-9 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Fukui Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Energy Metabolism / physiology Exercise Heart Failure / metabolism*, physiopathology Hemodynamics Humans Lung Diseases, Obstructive / metabolism*, physiopathology Magnetic Resonance Spectroscopy / diagnostic use Male Middle Aged Muscles / blood supply, metabolism*, physiopathology Phosphorus Isotopes |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 1992 Feb;5(2):151-4
[PMID:
1559577
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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