Document Detail

31P magnetic resonance spectroscopy of the medial temporal lobe of schizophrenic patients with neuroleptic-resistant marked positive symptoms.
MedLine Citation:
PMID:  7893768     Owner:  NLM     Status:  MEDLINE    
31P magnetic resonance spectroscopy was performed in 16 mediated schizophrenic patients with neuroleptic-resistant marked positive symptoms and in 16 healthy volunteers matched for age and sex in order to determine what changes in phosphorus metabolites are detected in such patients as compared to the controls. The schizophrenic patients showed an increased level of phosphodiesters in the bilateral medial temporal lobes. They also showed a decrease in the level of beta-ATP in the left medial temporal lobe. These findings suggest that schizophrenic patients with prominent positive symptoms refractory to neuroleptics may have a disturbance of bilateral membrane phospholipid and left-sided high-energy phosphate metabolism in the medial temporal lobe.
H Fukuzako; K Takeuchi; K Ueyama; T Fukuzako; Y Hokazono; K Hirakawa; K Yamada; T Hashiguchi; M Takigawa; T Fujimoto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  244     ISSN:  0940-1334     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-26     Completed Date:  1995-04-26     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  IM    
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Antipsychotic Agents / administration & dosage,  therapeutic use
Functional Laterality
Magnetic Resonance Spectroscopy*
Middle Aged
Phosphorus / metabolism*
Schizophrenia / drug therapy,  radiography*
Temporal Lobe / metabolism*,  radiography*
Reg. No./Substance:
0/Antipsychotic Agents; 7723-14-0/Phosphorus

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