| (31)P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla. | |
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MedLine Citation:
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PMID: 19697152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigation of phosphorus ((31)P) magnetic resonance spectroscopy under stress conditions provides a non-invasive tool to examine alterations in cardiac high-energy phosphate metabolism that may not be evident at rest. Our aim was to establish cardiac (31)P MR spectroscopy during leg exercise at 3T. The increased field strength should provide a higher signal to noise ratio than at lower field strengths. Furthermore, relatively high temporal resolution at a sufficiently fine spatial resolution should be feasible. (31)P MR spectra were obtained with a 3D acquisition weighted chemical shift imaging sequence in 20 healthy volunteers at rest, during dynamic physiological leg exercise and after recovery at 3T. Haemodynamic measurements were made throughout and the rate pressure product calculated. With exercise, the mean heart rate increased by 73%, achieving a mean increase in rate pressure product of 115%. The corrected PCr/ATP ratio for subjects at rest was 2.02 +/- 0.43, exercise 2.14 +/- 0.67 (P = 0.54 vs. rest) and at recovery 2.03 +/- 0.52 (P = 0.91 vs. rest, P = 0.62 vs. exercise). A cardiac (31)P MR spectroscopy physiological exercise-recovery protocol is feasible at 3T. There was no significant change in high-energy cardiac phosphate metabolite concentrations in healthy volunteers at rest, during physiological leg exercise or during recovery. When applied to patients with heart disease, this protocol should provide insights into physiological and pathological cardiac metabolism. |
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Authors:
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Lucy E Hudsmith; Damian J Tyler; Yaso Emmanuel; Steffen E Petersen; Jane M Francis; Hugh Watkins; Kieran Clarke; Matthew D Robson; Stefan Neubauer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-21 |
Journal Detail:
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Title: The international journal of cardiovascular imaging Volume: 25 ISSN: 1875-8312 ISO Abbreviation: Int J Cardiovasc Imaging Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-27 Completed Date: 2010-03-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100969716 Medline TA: Int J Cardiovasc Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 819-26 Citation Subset: IM |
Affiliation:
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The University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, Oxford, OX3 9DU, UK. lucyhudsmith@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Adult Blood Pressure Energy Metabolism* Exercise* Female Heart Rate Humans Imaging, Three-Dimensional Leg Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy* Male Muscle Contraction* Muscle, Skeletal / physiology* Myocardium / metabolism* Phosphocreatine / metabolism Phosphorus Isotopes / diagnostic use* |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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