Document Detail


31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy.
MedLine Citation:
PMID:  3778447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
31P-Nuclear magnetic resonance was used to monitor in situ phosphorus containing compounds in mammary tumors after photodynamic therapy, consisting of administration of hematoporphyrin derivative followed by photoradiation of the lesion. A rapid decrease in ATP along with an increase in Pi resonance intensities was observed. The beta-ATP/Pi ratio decreased by 1 hour, dropping in 2 to 8 hours to 0 to 20 percent of that found prior to photoradiation. Disrupted cells and pycnotic nuclei were observed 48 to 72 hours after photoradiation to a depth of approximately 5 mm. Together with previous studies in vitro, reduction in tumor ATP levels appears to be an early biochemical response to photodynamic therapy.
Authors:
T L Ceckler; R G Bryant; D P Penney; S L Gibson; R Hilf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  140     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-04     Completed Date:  1986-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / analysis*
Animals
Female
Magnetic Resonance Spectroscopy / diagnostic use*
Mammary Neoplasms, Experimental / analysis,  drug therapy*,  pathology
Phosphates / analysis
Photochemotherapy*
Rats
Rats, Inbred F344
Grant Support
ID/Acronym/Agency:
CA 11198/CA/NCI NIH HHS; CA 36856/CA/NCI NIH HHS; CA 40699/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Phosphates; 56-65-5/Adenosine Triphosphate

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