| 31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy. | |
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MedLine Citation:
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PMID: 3778447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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31P-Nuclear magnetic resonance was used to monitor in situ phosphorus containing compounds in mammary tumors after photodynamic therapy, consisting of administration of hematoporphyrin derivative followed by photoradiation of the lesion. A rapid decrease in ATP along with an increase in Pi resonance intensities was observed. The beta-ATP/Pi ratio decreased by 1 hour, dropping in 2 to 8 hours to 0 to 20 percent of that found prior to photoradiation. Disrupted cells and pycnotic nuclei were observed 48 to 72 hours after photoradiation to a depth of approximately 5 mm. Together with previous studies in vitro, reduction in tumor ATP levels appears to be an early biochemical response to photodynamic therapy. |
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Authors:
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T L Ceckler; R G Bryant; D P Penney; S L Gibson; R Hilf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 140 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-04 Completed Date: 1986-12-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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analysis* Animals Female Magnetic Resonance Spectroscopy / diagnostic use* Mammary Neoplasms, Experimental / analysis, drug therapy*, pathology Phosphates / analysis Photochemotherapy* Rats Rats, Inbred F344 |
| Grant Support | |
ID/Acronym/Agency:
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CA 11198/CA/NCI NIH HHS; CA 36856/CA/NCI NIH HHS; CA 40699/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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