| 31P magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono- and diesters at 3 T in the human brain: relation with age and spatial differences. | |
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MedLine Citation:
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PMID: 20669234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue levels of the compounds phosphocholine (PC), phosphoethanolamine (PE), glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE) can be studied by in vivo 31P MRS. However, the detection of the signals of these compounds suffers from low sensitivity and contamination by underlying broad resonances of other phosphorylated compounds. Improved sensitivity without this contamination can be achieved with a method for optimal polarisation transfer of 1H to 31P spins in these molecules, called selective refocused insensitive nuclei-enhanced polarisation transfer (sRINEPT). The aim of this study was to implement a three-dimensional magnetic resonance spectroscopic imaging (MRSI) version of sRINEPT on a clinical 3 T magnetic resonance system to obtain spatially resolved relative levels of PC, PE, GPC and GPE in the human brain as a function of age, which could be used as a reference dataset for clinical applications. Good signal-to-noise ratios were obtained from voxels of 17 cm(3) of the parietal and occipital lobes of the brain within a clinically acceptable measurement time of 17 min. Eighteen healthy subjects of different ages (16-70 years) were examined with this method. A strong inverse relation of the PE/GPE and PC/GPC ratios with age was found. Spatial resolution was sufficient to detect differences in metabolite ratios between white and grey matter. Moreover, we showed the feasibility of this method for clinical use in a pilot study of patients with brain tumours. The sRINEPT MRSI technique enables the exploration of phospholipid metabolism in brain diseases with a better sensitivity than was possible with earlier 31P MRS methods. |
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Authors:
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J P Wijnen; T W J Scheenen; D W J Klomp; A Heerschap |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: NMR in biomedicine Volume: 23 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
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Languages: eng Pagination: 968-76 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. j.wijnen@rad.umcn.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aging* Brain* / anatomy & histology, metabolism Brain Neoplasms / metabolism, pathology Esters / chemistry, metabolism* Glycerylphosphorylcholine / chemistry, metabolism Humans Imaging, Three-Dimensional / methods Magnetic Resonance Spectroscopy / methods* Middle Aged Phosphatidylethanolamines / chemistry, metabolism Phosphorus Isotopes / metabolism* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA118559/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Esters; 0/Phosphatidylethanolamines; 0/Phosphorus Isotopes; 1190-00-7/glycerophosphoethanolamine; 563-24-6/Glycerylphosphorylcholine |
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